The file in this folder contains a list of genetic variants and corresponding beta coefficients to construct the coronary artery disease (CAD) polygenic risk scores (PRS) featured in the following project:
 
Patel AP, Wang M, Ruan Y et al (2023). Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery disease.Nat Med. 2023 Jul 6. doi: 10.1038/s41591-023-02429-x. PMID: 37414900.
 
The PRS was constructed with HapMap3 SNPs from multiple-ancestry GWAS of CAD and related traits. See “GPS construction” in method session for details regarding the PRS.
 
 
## "PatelWang2023_GPSMult.txt.gz" -- best-performing PRS derived from multi-ancestry and multi-trait GWAS as described by Patel AP et al.
 
## chr:pos:a1:a0 = coordinates based on hg19
## a1 = effect allele. 
## a0 = reference allele. 
## MixBeta_2ndLayer = weight used for PRS construction